2-OXA-6-AZASPIRO[3.3]HEPTANE HCL
2-oxa-6-azaspiro[3.3]heptane
CAS: 174-78-7
Molecular Formula: C12H20N2O6
2-OXA-6-AZASPIRO[3.3]HEPTANE HCL - Names and Identifiers
2-OXA-6-AZASPIRO[3.3]HEPTANE HCL - Physico-chemical Properties
| Molecular Formula | C12H20N2O6 |
| Molar Mass | 288.3 |
| Density | 1.12 |
| Boling Point | 166℃ |
| Flash Point | 51℃ |
| pKa | 9.73±0.20(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
| Sensitive | Irritant |
| Refractive Index | 1.4750 to 1.4790 |
| MDL | MFCD11976178 |
| Use | Application of 2-oxa-6-aza-spiro [3,3] heptane can be used as an intermediate in organic synthesis and pharmaceutical intermediates for laboratory research and development processes and synthesis of pharmaceutical and chemical industries. |
2-OXA-6-AZASPIRO[3.3]HEPTANE HCL - Risk and Safety
| UN IDs | UN 1993 3/PG III |
| Hazard Class | 3 |
| Packing Group | III |
2-OXA-6-AZASPIRO[3.3]HEPTANE HCL - Introduction
2-oxa-6-azaspiro[3.3]heptane, often abbreviated as OASH, is an organic compound with the chemical formula C6H12N2O. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: OASH is a colorless to light yellow liquid.
-Melting point: about -15 ℃.
-Boiling point: About 186-188 ℃.
-Density: about 1.038g/cm³.
-Solubility: OASH is soluble in water, but also soluble in alcohol, ether and organic solvents.
Use:
OASH is mainly used in organic synthesis of Spiro reagents and catalysts. Its special Spiro structure can form a stable coordination compound with metal, which can be used to promote various organic reactions, such as carbonylation reaction, cyclization reaction and so on. At the same time, OASH can also be used as an intermediate in the synthesis of other compounds.
Method:
The preparation method of OASH is generally completed by a synthetic route of multi-step reaction. Here is one of the synthetic methods:
1. First, pentanone is reacted with ethyl acetate to generate pentanone acetate.
2. Under alcohol conditions, pentanone acetate reacts with p-aminophenol to generate pentanone acetate p-aminophenol ester.
3. Under alkaline conditions, pentanone acetate p-aminophenol ester reacts with sodium ammonium sulfite to generate pentanone acetate sodium ammonium sulfite.
4. Finally, sodium pentanone acetate ammonium sulfite reacts with phosphorus pentachloride to generate 2-oxa-6-azaspiro[3.3]heptane.
Safety Information:
- OASH is generally stable and relatively safe under normal conditions of use.
-However, avoid contact with skin, eyes and respiratory tract, and avoid swallowing.
-In industry and laboratories, safe practices should be observed, such as wearing appropriate protective equipment (e. G. Gloves, glasses, respirators, etc.).
-If you come into contact with OASH, rinse immediately with plenty of water and consult your doctor's advice.
Nature:
-Appearance: OASH is a colorless to light yellow liquid.
-Melting point: about -15 ℃.
-Boiling point: About 186-188 ℃.
-Density: about 1.038g/cm³.
-Solubility: OASH is soluble in water, but also soluble in alcohol, ether and organic solvents.
Use:
OASH is mainly used in organic synthesis of Spiro reagents and catalysts. Its special Spiro structure can form a stable coordination compound with metal, which can be used to promote various organic reactions, such as carbonylation reaction, cyclization reaction and so on. At the same time, OASH can also be used as an intermediate in the synthesis of other compounds.
Method:
The preparation method of OASH is generally completed by a synthetic route of multi-step reaction. Here is one of the synthetic methods:
1. First, pentanone is reacted with ethyl acetate to generate pentanone acetate.
2. Under alcohol conditions, pentanone acetate reacts with p-aminophenol to generate pentanone acetate p-aminophenol ester.
3. Under alkaline conditions, pentanone acetate p-aminophenol ester reacts with sodium ammonium sulfite to generate pentanone acetate sodium ammonium sulfite.
4. Finally, sodium pentanone acetate ammonium sulfite reacts with phosphorus pentachloride to generate 2-oxa-6-azaspiro[3.3]heptane.
Safety Information:
- OASH is generally stable and relatively safe under normal conditions of use.
-However, avoid contact with skin, eyes and respiratory tract, and avoid swallowing.
-In industry and laboratories, safe practices should be observed, such as wearing appropriate protective equipment (e. G. Gloves, glasses, respirators, etc.).
-If you come into contact with OASH, rinse immediately with plenty of water and consult your doctor's advice.
Last Update：2024-04-10 22:29:15
Supplier List
Featured ProductsSpot supply
Product Name: 2-Oxa-6-azaspiro[3.3]heptane Visit Supplier Webpage Request for quotationCAS: 174-78-7
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: 2-Oxa-6-azaspiro[3.3]heptane Request for quotationCAS: 174-78-7
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: 2-Oxa-6-azaspiro[3.3]heptane Visit Supplier Webpage Request for quotationCAS: 174-78-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: 2-Oxa-6-Azaspiro[3.3]heptane Visit Supplier Webpage Request for quotationCAS: 174-78-7
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: 2-oxa-6-azaspiro3.3heptane Visit Supplier Webpage Request for quotationCAS: 174-78-7
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: 2-Oxa-6-azaspiro[3.3]heptane Request for quotation
CAS: 174-78-7
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: +8613651600618
WhatsApp: +8613651600618
CAS: 174-78-7
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: +8613651600618
WhatsApp: +8613651600618
Featured ProductsSpot supply
Product Name: 2-Oxa-6-azaspiro[3.3]heptane Visit Supplier Webpage Request for quotationCAS: 174-78-7
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: 2-Oxa-6-azaspiro[3.3]heptane Request for quotationCAS: 174-78-7
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: 2-Oxa-6-azaspiro[3.3]heptane Visit Supplier Webpage Request for quotationCAS: 174-78-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: 2-Oxa-6-Azaspiro[3.3]heptane Visit Supplier Webpage Request for quotationCAS: 174-78-7
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: 2-oxa-6-azaspiro3.3heptane Visit Supplier Webpage Request for quotationCAS: 174-78-7
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: 2-Oxa-6-azaspiro[3.3]heptane Request for quotation
CAS: 174-78-7
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: +8613651600618
WhatsApp: +8613651600618
CAS: 174-78-7
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: +8613651600618
WhatsApp: +8613651600618
View History